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What is promethazine, and how does it work mechanism of action .
Information about Promethazine.
Administration of promethazine HCl (promethazine hydrochloride) has been associated with reported cholestatic jaundice.
It’s typically taken every four to six hours as needed. You can take this medicine with or without food.
Before having any laboratory test.tell your doctor and the laboratory personnel that you are taking promethazine.
The FDA has issued a black-box warning about the use of promethazine hydrochloride in children younger than 2 years because the drug could lead to severe or fatal breathing problems.
Promethazine hydrochloride tablets may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks.such as driving a vehicle or operating machinery. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates).narcotics.narcotic analgesics.general anesthetics.tricyclic antidepressants.and tranquilizers.may enhance impairment (see WARNINGS-CNS Depression and PRECAUTIONS – DRUG INTERACTIONS ). Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities.
drowsiness changes in blood pressure allergic skin reactions reduced platelet counts reduced white blood cell production breathing problems increased excitability abnormal movements.
There may be an increase in the risk of certain neurologic reactions that affect movement of muscles (EPS.see below) when promethazine is combined with medicines that also cause EPS. Such drugs include antipsychotics.metoclopramide (Metozolv ODT.Reglan).and amoxapine.
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promethazine products are contraindicated for use in pediatric patients less than two years of age see warnings-black box warning and use in pediatric patients .